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Runepowder Vial contains the fabled explosive of the gnomes. It can be obtained from Philomeen if you convince her to leave Grymforge on her own during the quest Find the Explosives.
Runepowder was said to be invented by Gaerdal Ironhand, the protector god of gnomes. A mere 23 vials were needed to repel an assault led by Kurtulmak and his Kobold Delvers.
Properties
Grenades
Single Use
Rarity: Rare
Weight: 0.2 kg / 0.4 lb
Price: 50 gp
Effect
5d4 + 18 (23~38) 
Force - The runepowder inside explodes when ignited, damaging everything in the vicinity.
- Automaically critically hits objects and environments.
AoE: 1 m / 3 ft (Radius)- Dexterity Saving Throw
Where to find
Obtained from Philomeen in Grymforge during quest Find the Explosives